Nobuteru Tojo Selected Research

5- chloro- 2- (3- (4- phenyl- 3,6- dihydro- 1(2H)- pyridinyl)propyl)- 4(3H)- quinazolinone

8/2004

A novel and potent poly(ADP-ribose) polymerase-1 inhibitor, FR247304 (5-chloro-2-[3-(4-phenyl-3,6-dihydro-1(2H)-pyridinyl)propyl]-4(3H)-quinazolinone), attenuates neuronal damage in in vitro and in vivo models of cerebral ischemia.

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Nobuteru Tojo Research Topics

Disease

3	Middle Cerebral Artery Infarction (Middle Cerebral Artery Syndrome) 09/2004 - 03/2004
2	Brain Ischemia (Cerebral Ischemia) 05/2007 - 08/2004
2	Thrombosis (Thrombus) 09/2004 - 03/2004
2	Stroke (Strokes) 09/2004 - 08/2004
1	Transient Ischemic Attack 05/2007
1	Ischemia 05/2007
1	Brain Injuries (Brain Injury) 08/2004
1	Neurodegenerative Diseases (Neurodegenerative Disease) 08/2004
1	Ischemic Stroke 03/2004
1	Neuroblastoma 01/2002
1	Hypoxia (Hypoxemia) 01/2002

Drug/Important Bio-Agent (IBA)

2	((S)- 2- acetylamino- 3- ((R)- (1- (3- (piperidin- 4- yl)propionyl)piperidin- 3- ylcarbonyl))amino) propionic acid trihydrateIBA 09/2004 - 03/2004
1	FR 901459IBA 05/2007
1	CalcineurinIBA 05/2007
1	Neuroprotective AgentsIBA 05/2007
1	Cyclosporine (Ciclosporin)FDA LinkGeneric 05/2007
1	Glycoproteins (Glycoprotein)IBA 09/2004
1	NAD (NADH)IBA 08/2004
1	5- chloro- 2- (3- (4- phenyl- 3,6- dihydro- 1(2H)- pyridinyl)propyl)- 4(3H)- quinazolinoneIBA 08/2004
1	Poly (ADP-Ribose) Polymerase-1IBA 08/2004
1	Adenosine Diphosphate (ADP)IBA 08/2004
1	EnzymesIBA 08/2004
1	Reactive Oxygen Species (Oxygen Radicals)IBA 08/2004
1	QuinazolinonesIBA 08/2004
1	ozagrelIBA 03/2004
1	propionic acid (potassium propionate)IBA 03/2004
1	Thrombin FDA Link 03/2004
1	ThromboxanesIBA 03/2004
1	argatroban (MPQA)FDA Link 03/2004
1	Proteins (Proteins, Gene)FDA Link 01/2002
1	Messenger RNA (mRNA)IBA 01/2002

Therapy/Procedure

1	Intraventricular Infusions 05/2007
1	Intravenous Injections 05/2007
1	Secondary Prevention 03/2004